Endocrine Abstracts

Background: The serum concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Pregnancy is associated with increases in plasma lipid profiles. Identifying the genetic determinants could provide novel insights into mechanisms of dyslipidemia and reveal avenues for developing new therapies. The objective of this study was to investigate the impact of six single nucleotide polymorphisms (SNPs) on serum lipid levels during pregnancy.<p ...

Background: Previous studies reported that direct injection of estrogen (E2) into different hypothalamic nuclei affects food intake, body weight and locomotor activity. We hypothesized that E2 signaling in the hypothalamus regulates glucose metabolism independently of circulating estrogen levels.Methods: We investigated the effects of hypothalamic estrogen administration on basal glucose production as well as on hepatic and peripher...

Background: Studies across the world have unveiled different prevalence of primary aldosteronism (PA) in distinct geographical areas and human races. However, owing to disparities in methodology and recruitment, the true incidence is still open. Especially information in Asian resistant hypertension is rare, so we determined to investigate the prevalence of PA in this population.Methods: We launched a large-scale, hospital-based national survey and enrol...

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...